| Chemical Properties | Back Directory | [Boiling point ]
506.5±60.0 °C(predicted) | [density ]
1.41±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
0.41±0.50(predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
TMDJ-035 is a selective RyR2 inhibitor. TMDJ-035 suppresses abnormal Ca2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. TMDJ-035is a tool for studying the mechanism and dynamics of RyR2 channel gating[1]. | [References]
[1] Ryosuke Ishida, et al.?A potent and selective cis-amide inhibitor of ryanodine receptor 2 as a candidate for cardiac arrhythmia treatment. European Journal of Medicinal Chemistry |
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