| Chemical Properties | Back Directory | [Boiling point ]
541.3±50.0 °C(predicted) | [density ]
1.304±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
13.30±0.30(predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue[1]. | [IC 50]
PPARγ | [References]
[1] Guo SY, et al. Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism. Eur J Med Chem. 2023 Nov 15;260:115729. DOI:10.1016/j.ejmech.2023.115729 |
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