| Identification | Back Directory | [Name]
1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- | [CAS]
2685786-29-0 | [Synonyms]
Neuraminidase-IN-10
1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-3-(1-ethylpropoxy)-5-[[[2-methoxy-4-(2-thienyl)phenyl]methyl]amino]-, (3R,4R,5S)- | [Molecular Formula]
C26H34N2O5S | [MOL File]
2685786-29-0.mol | [Molecular Weight]
486.62 |
| Hazard Information | Back Directory | [Uses]
Neuraminidase-IN-10 is a potent neuraminidase (NA) inhibitor with ?anti-influenza?activity. Neuraminidase-IN-10 is against H1N1, H5N1, and H5N8 with IC50 values of 2.6 nM, 5.1 nM, and 1.65 nM, respectively[1]. | [in vivo]
Neuraminidase-IN-10 (0.156 mM-10 mM; injected into the eggs) showed good protection against both H5N1 and H5N8 strains in a dose-dependent manner in a chicken embryonated egg model [1]. | Animal Model: | SPF Chicken Embryonated Egg[1] | | Dosage: | 0.156 mM; 0.625 mM; 2.5 mM; 10 mM | | Administration: | Injected into the egg | | Result: | were not as effective as OSC in this infection model, but also exhibited a certain therapeutic effect.The survival rates of?Neuraminidase-IN-10?(H5N1: 100 and 40%, respectively; H5N8: 100 and 100%, respectively)? at 2.5 mM and 10 mM[1]. |
| [References]
[1] Han Ju, et al. Iterative Optimization and Structure-Activity Relationship Studies of Oseltamivir Amino Derivatives as Potent and Selective Neuraminidase Inhibitors via Targeting 150-Cavity. J Med Chem. 2022 Aug 8. doi: 10.1021/acs.jmedchem.1c01970. DOI:10.1021/acs.jmedchem.1c01970 |
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