| Identification | Back Directory | [Name]
AP-22408 | [CAS]
268741-43-1 | [Synonyms]
AP-22408
AC1L9I7C
UNII-3U3L5QR4KV
Phosphonic acid, P,P'-[4-[(2S)-2-(acetylamino)-3-[[(5S)-3-(aminocarbonyl)-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-yl]amino]-3-oxopropyl]-1,2-phenylene]bis- | [Molecular Formula]
C30H41N3O10P2 | [MOL File]
268741-43-1.mol | [Molecular Weight]
665.61 |
| Hazard Information | Back Directory | [Uses]
AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy[1]. | [References]
[1] Shakespeare W, et al. Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9373-8. DOI:10.1073/pnas.97.17.9373 |
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