| Identification | Back Directory | [Name]
Benzamide, N-[1-ethyl-3-[[[[(4-fluorophenyl)methyl]amino]carbonyl]amino]-1H-indol-5-yl]-4-[(4-hydroxy-1-piperidinyl)methyl]- | [CAS]
2691937-03-6 | [Synonyms]
ATX inhibitor 20
Benzamide, N-[1-ethyl-3-[[[[(4-fluorophenyl)methyl]amino]carbonyl]amino]-1H-indol-5-yl]-4-[(4-hydroxy-1-piperidinyl)methyl]- | [Molecular Formula]
C31H34FN5O3 | [MOL File]
2691937-03-6.mol | [Molecular Weight]
543.63 |
| Hazard Information | Back Directory | [Uses]
ATX inhibitor 20 (compound 24) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.3 nM[1]. | [IC 50]
Autotaxin: 2.3 ± 0.31 nM (IC50) | [References]
[1] Jia F, et al. Structure-based linker exploration: Discovery of 1-ethyl-1H-indole analogs as novel ATX inhibitors. Bioorg Med Chem. 2020 Nov 15;28(22):115795. DOI:10.1016/j.bmc.2020.115795 |
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