| Identification | Back Directory | [Name]
7-Desacetoxy-6,7-dehydrogedunin | [CAS]
26927-01-5 | [Synonyms]
7DG
7DG >=95% (HPLC)
PKR inhibitor 7DG
7DG
(PKR inhibitor 7DG
7-Desacetoxy-6,7-dehydrogedunin
PKR Inhibitor III, 7DG CAS 26927-01-5 - Calbiochem
Oxireno[c]phenanthro[1,2-d]pyran-3,8(3aH,4bH)-dione, 1-(3-furanyl)-1,6a,7,10a,10b,11,12,12a-octahydro-4b,7,7,10a,12a-pentamethyl-, (1S,3aS,4aR,4bR,6aR,10aR,10bR,12aS)- | [Molecular Formula]
C26H30O5 | [MDL Number]
MFCD26961117 | [MOL File]
26927-01-5.mol | [Molecular Weight]
422.51 |
| Hazard Information | Back Directory | [Uses]
7DG (7-Desacetoxy-6,7-dehydrogedunin) is a protein kinase R (PKR) inhibitor. 7DG protects macrophages from lethal toxin-induced pyroptosis[1]. | [Biological Activity]
Cell permeable: yes''Primary Target
PKR''Reversible: yes | [References]
[1] Hett EC, et, al. Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis. Nat Chem Biol. 2013 Jun;9(6):398-405. DOI:10.1038/nchembio.1236
[2] Chukwurah E, et, al. A tale of two proteins: PACT and PKR and their roles in inflammation. FEBS J. 2021 Nov;288(22):6365-6391. DOI:10.1111/febs.15691 |
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