| Identification | Back Directory | [Name]
STARBURST(R) (PAMAM) DENDRIMER, GENERATION 4.5 | [CAS]
26937-01-9 | [Synonyms]
PAMAM G2, 90%
starburst(pamam)dendrimer
polyamidoaminedendrimer,generation1.0
PAMAM Dendrimer, Generation 4.5 solution
STARBURST(R) (PAMAM) DENDRIMER, GENERATION 4.5
2-Propenoicacid,methylester,polymerwith1,2-ethanediamine
Methylacrylat, Polymer mit Ethylendiamin mittlere Molmasse 6300 g/mol
STARBURST (PAMAM) DENDRIMER, GENERATION 4.5, 5% SOLUTION IN METHYL ALCOHOL
2-Propenoic acid, methyl ester, polymer with 1,2-ethanediamine polyamidoamine dendrimer, generation 1.0 | [Molecular Formula]
(C4H6O2.C2H8N2)x | [MDL Number]
MFCD00804247 | [MOL File]
26937-01-9.mol | [Molecular Weight]
146.19 |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
23/24/25-39/23/24/25 | [Safety Statements ]
36/37-45 | [RIDADR ]
UN 1230 3/PG 2 | [WGK Germany ]
1 | [TSCA ]
TSCA listed | [Toxicity]
rat,LDLo,oral,5gm/kg (5000mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"BEHAVIORAL: TREMOR,National Technical Information Service. Vol. OTS0556374, |
| Hazard Information | Back Directory | [Description]
PAMAM dendrimer G2.0 amine (PAMAM G2.0) is a polyamidoamine (PAMAM) dendrimer with amine termini.1 It is approximately 29 Å in diameter and has 16 surface groups. PAMAM G2.0 (15 mg/ml) in combination with erythromycin (Item No. 16486) enhances the solubility and antibacterial activity of erythromycin against S. aureus.2 It increases the cell growth rate of HEK293T and HeLa cells when used at concentrations ranging from 100 to 500 nM but is cytotoxic to the same cells when used at concentrations greater than or equal to 700 nM.3 In vivo, PAMAM G2.0 when administered in combination with fluorescein isothiocyanate-labeled dextran enhances its nasal absorption in rats.4WARNING This product is not for human or veterinary use. | [References]
[1] TISHA C. KING HEIDEN . Developmental toxicity of low generation PAMAM dendrimers in zebrafish[J]. Toxicology and applied pharmacology, 2007, 225 1: Pages 70-79. DOI: 10.1016/j.taap.2007.07.009
[2] KATARZYNA WINNICKA. The effect of PAMAM dendrimers on the antibacterial activity of antibiotics with different water solubility.[J]. Molecules, 2013, 18 7: 8607-8617. DOI: 10.3390/molecules18078607
[3] SRINIVAS PARIMI. Mechanistic Insight into Cell Growth, Internalization, and Cytotoxicity of PAMAM Dendrimers[J]. Biomacromolecules, 2009, 11 2: 382-389. DOI: 10.1021/bm9010134
[4] ZHENGQI DONG. Effects of polyamidoamine (PAMAM) dendrimers on the nasal absorption of poorly absorbable drugs in rats[J]. International Journal of Pharmaceutics, 2010, 393 1: Pages 245-253. DOI: 10.1016/j.ijpharm.2010.04.021 |
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| Company Name: |
Henan Alpha Chemical Co., Ltd.
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| Telephone: |
0371-55055611 18137792234 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList31206/0.htm |
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