| Identification | Back Directory | [Name]
9H-Pyrimido[4',5':4,5]thiazolo[3,2-a]pyrimidine-8-carboxylic acid, 2-amino-4-(4-bromophenyl)-7-phenyl-9-(3,4,5-trimethoxyphenyl)-, ethyl ester | [CAS]
2697171-03-0 | [Synonyms]
Topoisomerase II inhibitor 7
9H-Pyrimido[4',5':4,5]thiazolo[3,2-a]pyrimidine-8-carboxylic acid, 2-amino-4-(4-bromophenyl)-7-phenyl-9-(3,4,5-trimethoxyphenyl)-, ethyl ester | [Molecular Formula]
C32H28BrN5O5S | [MOL File]
2697171-03-0.mol | [Molecular Weight]
674.56 |
| Hazard Information | Back Directory | [Uses]
Topoisomerase II inhibitor 7 (compound 3a) is a potent inhibitor of topoisomerase II alpha subtype, with an IC50 of 3.19 μM. Topoisomerase II inhibitor 7 can induce cell cycle arrest and apoptosis[1]. | [IC 50]
topoisomerase II alpha: 3.19 μM (IC50) | [References]
[1] Nemr MTM, et, al. Design, synthesis and antiproliferative evaluation of new tricyclic fused thiazolopyrimidines targeting topoisomerase II: Molecular docking and apoptosis inducing activity. Bioorg Chem. 2020 Dec;105:104446. DOI:10.1016/j.bioorg.2020.104446 |
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