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269718-84-5

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269718-84-5 Structure

269718-84-5 Structure
IdentificationBack Directory
[Name]

Pardoprunox
[CAS]

269718-84-5
[Synonyms]

SLV-308
DU 126891
Pardoprunox
SLV-308; DU-126891
pardoprunox (SLV308)
Pardoprunox，DU 126891
7-(4-Methyl-1-piperazinyl)-2(3H)-benzoxazolone
2(3H)-Benzoxazolone, 7-(4-methyl-1-piperazinyl)-
7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one
[EINECS(EC#)]

604-604-1
[Molecular Formula]

C12H15N3O2
[MDL Number]

MFCD19443755
[MOL File]

269718-84-5.mol
[Molecular Weight]

233.27
Chemical PropertiesBack Directory
[density ]

1.258±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[pka]

9.15±0.70(Predicted)
Hazard InformationBack Directory
[Uses]

Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1].
[IC 50]

5-HT1A Receptor: 6.3 (pEC50); D2 Receptor: 8 (pEC50); D3 Receptor: 9.2 (pEC50)
[storage]

Store at -20°C
[References]

[1] Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608. DOI:10.1002/syn.20330
[2] Bronzova J, et al. Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease. Mov Disord. 2010 Apr 30;25(6):738-46. DOI:10.1002/mds.22948
[3] Bétry C, et al. In vivo effects of pardoprunox (SLV308), a partial D?/D? receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity. Synapse. 2011 Oct;65(10):1042-51. DOI:10.1002/syn.20936
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