| Identification | Back Directory | [Name]
Pardoprunox | [CAS]
269718-84-5 | [Synonyms]
SLV-308
DU 126891
Pardoprunox
SLV-308; DU-126891
pardoprunox (SLV308)
Pardoprunox，DU 126891
7-(4-Methyl-1-piperazinyl)-2(3H)-benzoxazolone
2(3H)-Benzoxazolone, 7-(4-methyl-1-piperazinyl)-
7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C12H15N3O2 | [MDL Number]
MFCD19443755 | [MOL File]
269718-84-5.mol | [Molecular Weight]
233.27 |
| Hazard Information | Back Directory | [Uses]
Pardoprunox (SLV-308) is a partial dopamine D2 and D3 receptor partial agonist and a serotonin 5-HT1A receptor agonist, with pEC50s of 8, 9.2, and 6.3, respectively[1]. | [IC 50]
5-HT1A Receptor: 6.3 (pEC50); D2 Receptor: 8 (pEC50); D3 Receptor: 9.2 (pEC50) | [storage]
Store at -20°C | [References]
[1] Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608. DOI:10.1002/syn.20330
[2] Bronzova J, et al. Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease. Mov Disord. 2010 Apr 30;25(6):738-46. DOI:10.1002/mds.22948
[3] Bétry C, et al. In vivo effects of pardoprunox (SLV308), a partial D?/D? receptor and 5-HT1A receptor agonist, on rat dopamine and serotonin neuronal activity. Synapse. 2011 Oct;65(10):1042-51. DOI:10.1002/syn.20936 |
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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