| Identification | Back Directory | [Name]
2-Naphthalenemethanamine, N-butyl-N-(3-phenylpropyl)- | [CAS]
2700896-78-0 | [Synonyms]
BChE-IN-14
2-Naphthalenemethanamine, N-butyl-N-(3-phenylpropyl)- | [Molecular Formula]
C24H29N | [MOL File]
2700896-78-0.mol | [Molecular Weight]
331.49 |
| Hazard Information | Back Directory | [Uses]
BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease[1]. | [in vivo]
BChE-IN-14 (15 mg/kg; p.o. for Aβ1-42 injection days 3-8) affects memory and cognitive function in AD mice model[1]. | Animal Model: | ICR mice with oligomerized Aβ1-42 peptide injection[1] | | Dosage: | 15 mg/kg | | Administration: | Oral gavage; 15 mg/kg for Aβ1-42 injection days 3-8 | | Result: | Improved memory and cognitive function in vivo and showed a shorter latency than donepezil.
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| [References]
[1] Lu X, et al. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2022 Sep 2;243:114729. DOI:10.1016/j.ejmech.2022.114729 |
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