| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2707510-30-1 | [Synonyms]
GRP78-IN-3
(S)-N-(3-Methyl-1-oxo-1-(thiazol-2-ylamino)butan-2-yl)-1H-indole-2-carboxamide | [Molecular Formula]
C17H18N4O2S | [MOL File]
2707510-30-1.mol | [Molecular Weight]
342.42 |
| Hazard Information | Back Directory | [Uses]
GRP78-IN-3 (Compound 8) is a selective Grp78 (HSPA5) inhibitor with an IC50 of 0.59 μM. GRP78-IN-3 is 7-fold selective for HspA5 compared to HspA9 (IC50 of 4.3 μM) and >20-fold selective for HspA5 compared to HspA2 (IC50 of 13.9 μM)[1]. | [IC 50]
HSPA5: 0.59 μM (IC50) | [References]
[1] Andrew J Ambrose, et al. Discovery and Development of a Selective Inhibitor of the ER Resident Chaperone Grp78. J Med Chem. 2022 Dec 14. DOI:10.1021/acs.jmedchem.2c01631 |
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