| Hazard Information | Back Directory | [Uses]
DNA-PK-IN-6 is a potent inhibitor of DNA-PK. DNA-PK-IN-6 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-6 enhances the sensitivity of tumor tissues to radiotherapy, overcomes the problem of agent resistance, and enhances the inhibitory effect on a variety of solid tumors and hematological tumors (extracted from patent WO2021197159A1, compound 6)[1]. | [References]
[1] Xinhai Chen, et al. Macrocyclic compounds as dna-pk inhibitors. Patent WO2021197159A1. |
|
|