2713974-32-2

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2713974-32-2 Structure

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[Name] INDEX NAME NOT YET ASSIGNED
[CAS] 2713974-32-2
[Synonyms] ZLD2218
[Molecular Formula] C22H18N4O
[MOL File] 2713974-32-2.mol
[Molecular Weight] 354.41

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[Uses] Considerable studies confirmed that BRD4 inhibition ameliorated kidney injury and fibrosis ，and ZLD2218 exhibited the most potent inhibitory activity against BRD4, with the IC50 value of 107 nM
[IC 50] BRD4 inhibitors: 107 nM (IC₅₀)
[References] [1] Tao S,et al. Discovery of indol-6-yl-pyrrolo[2,3-c]pyridin-7-one derivatives as bromodomain-containing protein 4 (BRD4) inhibitors for the treatment of kidney fibrosis. Eur J Med Chem. 2022 Mar 5;231:114153. DOI:10.1016/j.ejmech.2022.114153

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