| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 10mg/mL
ethanol: 5mg/mL | [form ]
solid | [color ]
light yellow | [InChI]
1S/C19H20ClN5/c1-25-10-7-14(8-11-25)19-17(16-6-9-21-12-22-16)18(23-24-19)13-2-4-15(20)5-3-13/h2-6,9,12,14H,7-8,10-11H2,1H3,(H,23,24) | [InChIKey]
WYWOBCJMDNZHAV-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
A cell-permeable trisubstituted pyrazole compound that acts as a highly potent ATP-competitive inhibitor of CK1δ and p38α (IC50 = 20 and 40 nM, respectively). Shown to affect p38β, PKA, JNK2, and JNK3 activity (IC50 = 2.3, 10.5, 19.7, and 69.7 µM, respectively) only at much higher concentations and exhibit little effect against a panel of 44 other commonly studied kinases, including p38δ/γ, even at a conentraion of 10 µM or higher. An excellent tool for studying p38-mediated responses both in cells in vitro and in animals in vivo. | [Biological Activity]
Cell permeable: yes''Primary Target
p38 MAP Kinase''Product competes with ATP.''Reversible: no''Target IC50: 20 and 40 nMagainst CK1δ and p38αrespectively |
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| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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