| Identification | Back Directory | [Name]
3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole | [CAS]
271576-80-8 | [Synonyms]
SD-06
SD-06-1
SD 0006
CS-2591
SD 0006(SD-06)
SD-06;SD 06;SD06
3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone
Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy- | [Molecular Formula]
C20H20ClN5O2 | [MDL Number]
MFCD17019341 | [MOL File]
271576-80-8.mol | [Molecular Weight]
397.86 |
| Chemical Properties | Back Directory | [Boiling point ]
652.6±55.0 °C(Predicted) | [density ]
1.367 | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO : 50 mg/mL (125.67 mM; Need ultrasonic) | [form ]
Powder | [pka]
9.39±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Definition]
ChEBI: SD-06 is a member of the class of pyrazoles that is 1H-pyrazole in which the hydrogens at positions 3, 4, and 5 are replaced by N-(hydroxyacetyl)piperidin-4-yl, pyrimidin-4-yl and p-chlorophenyl groups, respectively. It is a member of pyrazoles, a member of pyrimidines, a N-acylpiperidine, a member of monochlorobenzenes and a primary alcohol. | [Biological Activity]
SD 0006 (SD-06) is an orally potent, selective, ATP-competitive, and potent diarylpyrazole inhibitor of p38α MAPK with IC50 of 110 nM. | [in vitro]
SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate. | [in vivo]
SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy.It(3.75, 7.5 and 15 mg/kg; po; bid) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling. | [target]
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| Company Name: |
LETOPHARM LIMITED
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| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
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| Telephone: |
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| Website: |
www.spiropharma.com.cn |
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