| Identification | Back Directory | [Name]
Benzonitrile, 4-[[4-[[2,6-difluoro-4-(4-pyridinyl)phenyl]amino]-5-methyl-2-pyrimidinyl]amino]- | [CAS]
2719675-72-4 | [Synonyms]
HIV-1 inhibitor-16
Benzonitrile, 4-[[4-[[2,6-difluoro-4-(4-pyridinyl)phenyl]amino]-5-methyl-2-pyrimidinyl]amino]- | [Molecular Formula]
C23H16F2N6 | [MOL File]
2719675-72-4.mol | [Molecular Weight]
414.41 |
| Hazard Information | Back Directory | [Uses]
HIV-1 inhibitor-16 (compound 7a) is a highly potent HIV-1 inhibitor with an EC50 value of 1.3 nM for HIV-1 WT. HIV-1 inhibitor-16 also has certain inhibitory activity against HIV-1 K103N, E138K, Y181C and L100I strains with EC50s of 5.4 nM, 9.2 nM, 22 nM and 35 nM. HIV-1 inhibitor-16 has?favorable solubility and liver microsome stability, and does not exhibit apparent CYP enzymatic inhibitory activity or acute toxicity[1]. | [IC 50]
HIV-1 (WT): 1.3 nM (EC50); HIV-1 (K103N): 5.4 nM (EC50); HIV-1 (E138K): 9.2 nM (EC50); HIV-1 (Y181C): 22 nM (EC50); HIV-1 (L100I): 35 mM (EC50) | [References]
[1] Ding L, et al. Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. J Med Chem. 2022;6 DOI:10.1021/acs.jmedchem.1c01676 |
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