| Identification | Back Directory | [Name]
[2,7]NAPHTHYRIDIN-1-YLAMINE | [CAS]
27225-00-9 | [Synonyms]
2,7phthyridin-1-ylamine
2,7-Naphthyridin-1-amine
1-Amino-2,7-naphthyridine
[2,7]NAPHTHYRIDIN-1-YLAMINE | [Molecular Formula]
C8H7N3 | [MDL Number]
MFCD11506147 | [MOL File]
27225-00-9.mol | [Molecular Weight]
145.16 |
| Chemical Properties | Back Directory | [Boiling point ]
363.7±27.0 °C(Predicted) | [density ]
1.292±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C(protect from light) | [pka]
5.54±0.30(Predicted) | [Appearance]
White to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
To 4-((E)-2-dimethylamino vinyl) nicotinonitrile (253 g) was added ammonium formate (810 g) followed by acetic acid (300 mL) in a 4 L reaction vessel. The reaction mixture was heated to reflux at 115°C for 20 hours. Upon completion of the reaction, it was cooled to room temperature, diluted with the addition of water (5 L) and extracted several times with dichloromethane (0.5 L x 10). After combining the organic phases, the pH of the aqueous phase was adjusted with sodium hydroxide (160 g) to 10. Subsequently, the aqueous phase was extracted with methyl tert-butyl ether, and the organic phase was separated and dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure, and after drying, 2,7-naphthyridin-1-amine (59 g) was obtained with a molecular weight of 145.16 g/mol (M+H measured value of 146), and the NMR spectrum was consistent with the target product. | [References]
[1] Patent: US2015/252041, 2015, A1. Location in patent: Paragraph 0166 |
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| Company Name: |
SynAsst Chemical.
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021-60343070 |
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www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Wuxi AppTec
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022-59987777 13552403979 |
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www.labnetwork.com |
| Company Name: |
3A Chemicals
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400-668-9898 |
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www.3achem.com |
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