| Identification | Back Directory | [Name]
INDEX NAME NOT YET ASSIGNED | [CAS]
2725863-08-9 | [Synonyms]
COX-2-IN-32
3-(4-(4-methoxyphenoxy)phenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one | [Molecular Formula]
C25H24O6 | [MOL File]
2725863-08-9.mol | [Molecular Weight]
420.46 |
| Hazard Information | Back Directory | [Uses]
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM)[1]. | [IC 50]
COX-2 | [References]
[1] Emam SH, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021 Feb;107:104630. DOI:10.1016/j.bioorg.2021.104630 |
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