| Identification | Back Directory | [Name]
Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- | [CAS]
2728780-74-1 | [Synonyms]
Nrf2 activator-6
Cyclopentanecarboxylic acid, 2-[[(1S)-5-chloro-7-fluoro-3,4-dihydro-1-[(6-oxo-5-azaspiro[2.4]hept-5-yl)methyl]-8-[(4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyridin-3-yl)methoxy]-2(1H)-isoquinolinyl]carbonyl]-1-methyl-, (1S,2R)- | [Molecular Formula]
C31H37ClFN5O5 | [MOL File]
2728780-74-1.mol | [Molecular Weight]
614.11 |
| Chemical Properties | Back Directory | [Boiling point ]
843.0±75.0 °C(Predicted) | [density ]
1.57±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
4.65±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Nrf2 activator-6, a tetrahydroisoquinoline compound, is a Nrf2 activator. Nrf2 activator-6 has an IC50 of 5 nM for inhibiting the Kelch domain-Nrf2 interaction (WO2021214470A1; Example 4)[1]. | [References]
[1] Cathy Louise LUCAS, et al. Tetrahydroisoquinoline compounds as nrf2 activators. WO2021214470A1. |
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