| Identification | Back Directory | [Name]
1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE | [CAS]
273-05-2 | [Synonyms]
3H-1,2,3-Triazolo[4,5-c]pyridine
1H-1,2,3-TRIAZOLO[4,5-C]PYRIDINE | [Molecular Formula]
C5H4N4 | [MDL Number]
MFCD02670924 | [MOL File]
273-05-2.mol | [Molecular Weight]
120.11 |
| Chemical Properties | Back Directory | [Melting point ]
186-187 °C | [Boiling point ]
428.9±18.0 °C(Predicted) | [density ]
1.472±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [pka]
7.00±0.70(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Uses]
3H-1,2,3-Triazolo[4,5-c]pyridine is an N-acylating and N-alkoxycarbonylation reagent that can be used as a P2X7 modulator for therapy. It can also be used as an inhibitor of hormone-sensitive lipase (HSL) and endothelial lipase (EL). | [Synthesis]
The general procedure for the synthesis of 3H-1,2,3-triazolo[4,5-c]pyridine from 3,4-diaminopyridine was as follows: 3,4-diaminopyridine (2.0 g, 0.048 mol) was dissolved in a 2 N aqueous hydrochloric acid solution (25 mL) and the solution was cooled to 0 °C. Subsequently, sodium nitrite (1.9 g, 0.027 mol) was dissolved in distilled water (3 mL) and slowly added to the above cooled solution with continuous stirring for 1 hour. Upon completion of the reaction, the resulting solid product was collected by filtration and washed with distilled water to finally obtain 3H-1,2,3-triazolo[4,5-c]pyridine (1.96 g, 89% yield) as a yellow solid. | [References]
[1] Patent: KR101798840, 2017, B1. Location in patent: Paragraph 0372-0375
[2] Tetrahedron Letters, 1997, vol. 38, # 50, p. 8607 - 8610 |
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