| Identification | Back Directory | [Name]
BAY 2965501 | [CAS]
2732902-08-6 | [Synonyms]
BAY 2965501
(R)-2-((4-amino-5-(4-methoxybenzoyl)thiazol-2-yl)(4-fluorophenyl)amino)propanamide
(2R)-2-[[4-Amino-5-(4-methoxybenzoyl)-2-thiazolyl](4-fluorophenyl)amino]propanamide | [Molecular Formula]
C20H19FN4O3S | [MOL File]
2732902-08-6.mol | [Molecular Weight]
414.46 |
| Chemical Properties | Back Directory | [Boiling point ]
681.7±65.0 °C(Predicted) | [density ]
1.383±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [form ]
Solid | [pka]
15.27±0.50(Predicted) | [color ]
Light yellow to yellow | [InChI]
InChI=1S/C20H19FN4O3S/c1-11(19(23)27)25(14-7-5-13(21)6-8-14)20-24-18(22)17(29-20)16(26)12-3-9-15(28-2)10-4-12/h3-11H,22H2,1-2H3,(H2,23,27)/t11-/m1/s1 | [InChIKey]
HSBUVKDEUUJREZ-LLVKDONJSA-N | [SMILES]
C(N)(=O)[C@H](N(C1=NC(N)=C(C(=O)C2=CC=C(OC)C=C2)S1)C1=CC=C(F)C=C1)C |
| Hazard Information | Back Directory | [Uses]
BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer[1]. | [in vivo]
BAY-2965501 inhibits tumor growth inhibition in an F9 testicular teratoma model, and the combination of BAY-2965501 with immune checkpoint blockade results in additive or synergistic effects[3].
| [References]
[1] Schubert N, et al. Phosphorylated extracellular signal-regulated kinase (pERK) activation in T effector cells as a target engagement biomarker for the DGKζ inhibitor BAY2965501 in clinical trials. Cancer Research, 2023, 83(7_Supplement): 2116-2116.
[2] Rienk Offringa, et al. 926BAY 2965501: a highly selective DGK zeta inhibitor for cancer immunotherapy. Regular and Young Investigator Award Abstracts. Immune Cell Types and Biology.
[3] Schlicher L, et al. Small molecule inhibitors for cancer immunotherapy and associated biomarkers - the current status. Front Immunol. 2023 Oct 31;14:1297175. DOI:10.3389/fimmu.2023.1297175 |
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ChemShuttle, Inc.
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0510-83588313-811 18800520310 |
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https://www.jiehuapharma.com/ |
| Company Name: |
Wuhan Topule
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+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
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