ChemicalBook--->CAS DataBase List--->27349-66-2

27349-66-2

27349-66-2 Structure

27349-66-2 Structure
IdentificationBack Directory
[Name]

3-(ChloroMethyl)pyridazine hydrochloride
[CAS]

27349-66-2
[Synonyms]

3-(CHLOROMETHYL)PYRIDAZINE HCL
3-(ChloroMethyl)pyridazine hydrochloride
[Molecular Formula]

C5H6Cl2N2
[MDL Number]

MFCD19705404
[MOL File]

27349-66-2.mol
[Molecular Weight]

165.021
Chemical PropertiesBack Directory
[storage temp. ]

Inert atmosphere,2-8°C
[Appearance]

Light brown to brown Solid
Safety DataBack Directory
[Symbol(GHS) ]


GHS07,GHS05
[Signal word ]

Danger
[Hazard statements ]

H312-H302-H332-H315-H318-H335
[Precautionary statements ]

P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P280-P305+P351+P338-P310
[HS Code ]

2933998090
Spectrum DetailBack Directory
[Spectrum Detail]

3-(ChloroMethyl)pyridazine hydrochloride(27349-66-2)1HNMR
Hazard InformationBack Directory
[Synthesis]

3-METHYLPYRIDAZINE

1632-76-4

Trichloroisocyanuric acid

87-90-1

3-(ChloroMethyl)pyridazine hydrochloride

27349-66-2

Method B: Synthesis of 3-(chloromethyl)pyridazine. Trichloroisocyanuric acid (148 mg, 0.6 mmol) was added batchwise to a chloroform solution of 3-methylpyridazine (145 μL, 1.6 mmol) under reflux conditions. The reaction mixture was stirred at reflux overnight. After completion of the reaction, the mixture was cooled to room temperature and filtered. The filtrate was diluted with dichloromethane and washed sequentially with 1 M aqueous sodium hydroxide and saturated saline. The organic phase was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 3-(chloromethyl)pyridazine hydrochloride (205 mg, 80% yield). Mass spectrum (ESI): calculated value C5H5ClN2, 128.0; measured value m/z, 129 [M + H]+. Intermediate 3: 5-(chloromethyl)pyrimidine hydrochloride.

[References]

[1] Patent: WO2018/67786, 2018, A1. Location in patent: Page/Page column 103; 104
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