| Chemical Properties | Back Directory | [Boiling point ]
521.748±50.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.103±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [solubility ]
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml |
| Hazard Information | Back Directory | [Description]
Prostaglandin J2-d4 is intended for use as an internal standard for the quantification of prostaglandin J2 by GC- or LC-MS. Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.1 PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.2,3 PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.4 However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself. | [Uses]
Prostaglandin J2-d4 is the deuterium labeled Prostaglandin J2[1]. | [References]
1. Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro J. Biol. Chem. 258(19),11713-11718(1983).
2. Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues J. Med. Chem. 26(6),790-799(1983).
3. Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2 Prostaglandins Leukot. Med. 16(2),131-146(1984).
4. Fukushima, M. Prostaglandin J2 - anti-tumor and anti-viral activities and the mechanisms involved Eicosanoids 3(4),189-199(1990). |
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