| Identification | Back Directory | [Name]
4-Quinolinemethanol, α-[[[(1S)-1-(methoxymethyl)-2-phenylethyl]amino]methyl]-2,8-bis(trifluoromethyl)-, (αS)- | [CAS]
2747280-03-9 | [Synonyms]
Antimalarial agent 10
4-Quinolinemethanol, α-[[[(1S)-1-(methoxymethyl)-2-phenylethyl]amino]methyl]-2,8-bis(trifluoromethyl)-, (αS)- | [Molecular Formula]
C23H22F6N2O2 | [MOL File]
2747280-03-9.mol | [Molecular Weight]
472.43 |
| Hazard Information | Back Directory | [Uses]
Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC50 values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is[1]. | [References]
[1] Dassonville-Klimpt A, et al. Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity. Eur J Med Chem. 2022;228:113981. DOI:10.1016/j.ejmech.2021.113981 |
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