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2752378-78-0

2752378-78-0 Structure

2752378-78-0 Structure
IdentificationBack Directory
[Name]

Benzoic acid, 4-[2-[[[(2E)-2-[(5-cyano-7-methyl-1H-indol-3-yl)methylene]hydrazinyl]iminomethyl]amino]ethyl]-, methyl ester
[CAS]

2752378-78-0
[Synonyms]

RXFP3/4 agonist 2
Benzoic acid, 4-[2-[[[(2E)-2-[(5-cyano-7-methyl-1H-indol-3-yl)methylene]hydrazinyl]iminomethyl]amino]ethyl]-, methyl ester
[Molecular Formula]

C22H22N6O2
[MOL File]

2752378-78-0.mol
[Molecular Weight]

402.45
Chemical PropertiesBack Directory
[Boiling point ]

638.3±65.0 °C(Predicted)
[density ]

1.27±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Solid
[pka]

14.75±0.30(Predicted)
[color ]

White to pink
Hazard InformationBack Directory
[Description]

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].

[Uses]

RXFP3/4 agonist 2 is a potent, nonpeptide dual RXFP3/4 agonist (EC50=3.1 and 2.7 nM). RXFP3/4 agonist 2 also potently promotes interactions between RXFP3 and β-arrestin-2 with EC50 values in the range of 10-22 nM[1].
[References]

[1] Guan D, et al. Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies. J Med Chem. 2021;64(24):17866-17886. DOI:10.1021/acs.jmedchem.1c01081
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