| Identification | Back Directory | [Name]
4ALPHA-PHORBOL 12,13-DIDECANOATE | [CAS]
27536-56-7 | [Synonyms]
4a-PDD
4ALPHA-PDD
4a-Phorbol-12,13-didecanoate
4α-phorbol 12-13-dicaprinate
4alpha-Phorbol 12,13-dideconate
4ALPHA-PHORBOL 12-13-DICAPRINATE
4ALPHA-PHORBOL 12,13-DIDECANOATE
4A-PHORBOL 12,13-DIDECANOATE, 99+%
4α-Phorbol 12,13-Didecanoate, >99%
phorbol (4alpha-) 12,13-didecanoate
4α-Phorbol 12-13-dicaprinate, 4αPDD
4-alpha-Phorbol 12,13-Didecanoate >99%
4A-PHORBOL 12,13-DIDECANOATE WEAK PROTEI N KINASE C
Decanoic acid, 1,1A,1B,4,4A,5,7A,7B,8,9-decahydro-4A,7B-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-9ah-cyclopropa(3,4)benz(1,2-E)azulene-9,9A-diyl ester, (1ar-(1aalpha,1bbeta,4aalpha,7aalpha,7balpha,8alpha,9beta,9aalpha))- | [Molecular Formula]
C40H64O8 | [MDL Number]
MFCD00036737 | [MOL File]
27536-56-7.mol | [Molecular Weight]
672.93 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C
| [solubility ]
DMSO: soluble
| [form ]
solid
| [color ]
white
| [BRN ]
2514324 | [InChIKey]
DGOSGFYDFDYMCW-OEFRVDPMSA-N | [SMILES]
O([C@]21[C@H]([C@H]3[C@@]([C@H]4[C@@](CC(=C3)CO)(C(=O)C(=C4)C)O)([C@@H]([C@H]2OC(=O)CCCCCCCCC)C)O)C1(C)C)C(=O)CCCCCCCCC |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
26/27/28-40-43 | [Safety Statements ]
36/37/39-45 | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [F ]
8-10 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 1 Dermal
Acute Tox. 1 Inhalation
Acute Tox. 2 Oral
Carc. 2
Resp. Sens. 1
Skin Corr. 1B
Skin Sens. 1 |
| Hazard Information | Back Directory | [Uses]
4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:
- to study its effects on Madin-Darby canine kidney (MDCK) cells
- to study its effects on Ca2+ influx in mice fallopian tubal cells
- to study its effects on hind paw swelling in mice
| [Definition]
ChEBI: 4alpha-phorbol 12,13-didecanoate is a phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted to the corresponding decanoate esters. A Trpv4-specific ligand. It has a role as a TRPV4 agonist. It is a phorbol ester, a decanoate ester, a tertiary alpha-hydroxy ketone, a diester and a primary allylic alcohol. | [Biochem/physiol Actions]
4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|