| Identification | Back Directory | [Name]
2'H-Chola-2,5-dieno[3,2-c]pyrazol-24-one, 2'-acetyl-4,4-dimethyl-24-(4-morpholinyl)- | [CAS]
2754254-07-2 | [Synonyms]
QH536
2'H-Chola-2,5-dieno[3,2-c]pyrazol-24-one, 2'-acetyl-4,4-dimethyl-24-(4-morpholinyl)- | [Molecular Formula]
C33H49N3O3 | [MOL File]
2754254-07-2.mol | [Molecular Weight]
535.77 |
| Hazard Information | Back Directory | [Uses]
QH536 (Compound 29) is a potent HMGCR degrader with an EC50 of 0.22 μM. QH536 has no side-effect of inducing cholesterol accumulation in cells. QH536 shows anti-inflammatory and can be used for cardiovascular disease and nonalcoholic steatohepatitis research[1]. | [References]
[1] Li XZ, et al. Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol. Eur J Med Chem. 2022 Jun 5;236:114323. DOI:10.1016/j.ejmech.2022.114323 |
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