| Identification | Back Directory | [Name]
Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- | [CAS]
2755415-30-4 | [Synonyms]
SOS1-IN-7
Pyrido[2,3-d]pyrimidin-7(8H)-one, 4-[[(1R)-1-[3-(difluoromethyl)-2-fluorophenyl]ethyl]amino]-6-(cis-1,4-dihydroxycyclohexyl)-2-methyl- | [Molecular Formula]
C23H25F3N4O3 | [MOL File]
2755415-30-4.mol | [Molecular Weight]
462.46 |
| Hazard Information | Back Directory | [Uses]
SOS1-IN-7 (compound 18-p1) is a potent SOS1 inhibitor with IC50s of 20 and 67 nM for SOS1-G12D and SOS1-G12V, respectively[1]. | [IC 50]
SOS1-G12D: 20 nM (IC50); SOS1-G12V: 67 nM (IC50) | [References]
[1] Pyridine-pyrimidine derivative, preparation method therefor and pharmaceutical use thereof. WO2021249519A1. |
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