| Identification | Back Directory | [Name]
quinidine polygalacturonate | [CAS]
27555-34-6 | [Synonyms]
Quinilac
Ritmocor
Sineflutter
Naticardina
Qalactoquin
D-Galacturonic acid, homopolymer, compd. with (9S)-6'-methoxycinchonan-9-ol | [Molecular Formula]
C26H34N2O9 | [MOL File]
27555-34-6.mol | [Molecular Weight]
518.556 |
| Hazard Information | Back Directory | [Uses]
Quinidine polygalacturonate is an antiarrhythmic agent. Quinidine polygalacturonate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine polygalacturonate is also a K+ channel blocker with an IC50 of 19.9 μM, and can induce apoptosis. Quinidine polygalacturonate can be used for malaria research[1][2][3][4]. | [in vivo]
Quinidine polygalacturonate shows effects on the PTZ-induced seizure threshold[5]. | Animal Model: | Male mice of the NMRI strain (age 5-6 weeks and weight 25-30 g)[5] | | Dosage: | 10, 20, and 30 mg/kg | | Administration: | Intraperitoneal injection; 10, 20, and 30 mg/kg; once | | Result: | Increased the threshold dose for the onset to tonic hind limb extension at a dose of 30 mg/kg, compared to the saline-treated control group (p<0.05). |
| [IC 50]
Plasmodium | [References]
[1] Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103(3):1807-13. DOI:10.1111/j.1476-5381.1991.tb09867.x
[2] Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. Pharmacol Ther. 1983;23(2):179-91. DOI:10.1016/0163-7258(83)90012-8
[3] Moody DE, et al. Quinidine inhibits in vivo metabolism of amphetamine in rats: impact upon correlation between GC/MS and immunoassay findings in rat urine. J Anal Toxicol. 1990 Sep-Oct;14(5):311-7. DOI:10.1093/jat/14.5.311
[4] Sang-Yun Lee, et al. Hydrocinchonine, cinchonine, and quinidine potentiate paclitaxel-induced cytotoxicity and apoptosis via multidrug resistance reversal in MES-SA/DX5 uterine sarcoma cells. Environ Toxicol. 2011 Aug;26(4):424-31. DOI:10.1002/tox.20568
[5] Hassan Jamali, et al. Effect of dextromethorphan/quinidine on pentylenetetrazole- induced clonic and tonic seizure thresholds in mice. Neurosci Lett. 2020 Jun 11;729:134988. DOI:10.1016/j.neulet.2020.134988 |
|
|