Identification | Back Directory | [Name]
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, 7-[(2-fluoro-4-pyridinyl)methyl]- | [CAS]
2757070-32-7 | [Synonyms]
7H-Pyrrolo[3,2-f]quinazoline-1,3-diamine, 7-[(2-fluoro-4-pyridinyl)methyl]- | [Molecular Formula]
C16H13FN6 | [MOL File]
2757070-32-7.mol | [Molecular Weight]
308.31 |
Hazard Information | Back Directory | [Uses]
Fluorofolin is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.5?nM. Fluorofolin exhibits significant activity against P. aeruginosa[1]. | [in vivo]
In mice, Fluorofolin displays favourable plasma protein binding (71.7% bound, 91.9% recovery). Upon oral administration, fluorofolin achieved a peak concentration of 4.0?μg/mL with a half-life of 12.1?h[1]. | [References]
[1] Connor Chain, et al. A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting. Nat Microbiol. 2024 May;9(5):1207-1219. DOI:10.1038/s41564-024-01665-2 |
|
|