| Identification | Back Directory | [Name]
2-Pyrimidinamine, N-[(1-methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)- | [CAS]
2757254-99-0 | [Synonyms]
2-Pyrimidinamine, N-[(1-methyl-1H-imidazol-4-yl)methyl]-4-(4-methyl-1-piperidinyl)- | [Molecular Formula]
C15H22N6 | [MOL File]
2757254-99-0.mol | [Molecular Weight]
286.38 |
| Chemical Properties | Back Directory | [Boiling point ]
550.3±60.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in ethanol and to 100 mM in DMSO | [form ]
Solid | [pka]
7.88±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
TP-040 (O-GlcNAcase-IN-1) is a potent and novel OGA inhibitor with an IC50 value of 46 nM. | [Biological Activity]
O-GlcNAcase-IN-1 is a potent and novel OGA inhibitor with an IC50 value of 46 nM. | [storage]
Store at -20°C | [References]
[1]. Tawada M, et al. Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization. J Med Chem. 2021 Jan 28;64(2):1103-1115. |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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