| Hazard Information | Back Directory | [Uses]
HSD17B13-IN-21 (compound 17) is a ppotent inhibitor of hydroxysteroid 17?-dehydrogenase 13 (HSD17B13), with the IC50 of ＜ 0.1 μM and? ＜ 1 μM estradiol and Leukotriene B3 as substrates, respectively. HSD17B13-IN-21? plays an important role in nonalcoholic fatty liver diseases (NAFLDs) including NASH (nonalcoholic steatohepatitis)[1]. | [References]
[1] Inipharm, Inc. Preparation of thiophene carboxamides as HSD17β13 inhibitors and uses thereof. World Intellectual Property Organization, WO2022020714 A1 2022-01-27 |
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