| Identification | Back Directory | [Name]
1-Butanone, 1-[(2S)-2-[[(2S)-2-(1H-imidazol-2-yl)-1-pyrrolidinyl]carbonyl]-1-pyrrolidinyl]-4-phenyl- | [CAS]
2760543-16-4 | [Synonyms]
1-Butanone, 1-[(2S)-2-[[(2S)-2-(1H-imidazol-2-yl)-1-pyrrolidinyl]carbonyl]-1-pyrrolidinyl]-4-phenyl- | [Molecular Formula]
C22H28N4O2 | [MOL File]
2760543-16-4.mol | [Molecular Weight]
380.48 |
| Chemical Properties | Back Directory | [Boiling point ]
696.6±55.0 °C(Predicted) | [density ]
1.237±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.85±0.10(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PREP inhibitor-1 (compound 27a) is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC50 < 1 nM). | [References]
[1] P?tsi HT, et al. 2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors. ACS Med Chem Lett. 2021 Sep 17;12(10):1578-1584. DOI:10.1021/acsmedchemlett.1c00399 |
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