| Identification | Back Directory | [Name]
Benzo[b]thiophene-3-acetamide, α-[(2-chloroacetyl)[4-(5-oxazolyl)phenyl]amino]-N-(2-phenylethyl)- | [CAS]
2761004-85-5 | [Synonyms]
Benzo[b]thiophene-3-acetamide, α-[(2-chloroacetyl)[4-(5-oxazolyl)phenyl]amino]-N-(2-phenylethyl)- | [Molecular Formula]
C29H24ClN3O3S | [MOL File]
2761004-85-5.mol | [Molecular Weight]
530.04 |
| Chemical Properties | Back Directory | [Boiling point ]
790.5±60.0 °C(Predicted) | [density ]
1.342±0.06 g/cm3(Predicted) | [solubility ]
Chloroform: soluble | [form ]
Solid | [pka]
13.83±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
GPX4-IN-3 (26a) is a potent glutathione peroxidase 4 (GPX4) inhibitor as a selective ferroptosis inducer. GPX4-IN-3 (26a) exhibits 71.7% inhibition for GPX4 with 1 μM[1]. | [in vivo]
GPX4-IN-3 (26a) exertes antitumor activity and good biological safety in vivo[1].
| Animal Model: | Mouse 4T1 xenograft model[1]. | | Dosage: | 15 and 30 mg/kg. | | Administration: | Intravenous injection, every two days for a total of five times. | | Result: | Significantly suppress tumor growth with a tumor growth inhibition (TGI) value of 33.2 and 55.1% at 15 and 30 mg/kg, respectively. |
| [References]
[1] Congjun Xu, et al. Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. J Med Chem. 2021 Sep 23;64(18):13312-13326. DOI:10.1021/acs.jmedchem.1c00569 |
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