| Identification | Back Directory | [Name]
1H-Purine-2,6-dione, 8-bromo-1,7-bis[(4-bromophenyl)methyl]-3,7-dihydro-3-methyl- | [CAS]
2761321-26-8 | [Synonyms]
BRD4-BD1-IN-2
1H-Purine-2,6-dione, 8-bromo-1,7-bis[(4-bromophenyl)methyl]-3,7-dihydro-3-methyl- | [Molecular Formula]
C20H15Br3N4O2 | [MOL File]
2761321-26-8.mol | [Molecular Weight]
583.07 |
| Hazard Information | Back Directory | [Uses]
BRD4-BD1-IN-2 is a selective BRD4-BD1 inhibitor, with an IC50 of 2.51 μM (20-times greater than that of BD2). BRD4-BD1-IN-2 can be used in studies of cancer and cardiovascular diseases[1]. | [IC 50]
BRD4-BD1: 2.51 μM (IC50); BRD4-BD2: ＞50 μM (IC50) | [References]
[1] Chang Y, et al. Design, synthesis, biological evaluation, and molecular docking of 1, 7-dibenzyl-substituted theophylline derivatives as novel BRD4-BD1-selective inhibitors. Medicinal Chemistry Research, 2021, 30(8): 1453-1468. |
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