| Identification | Back Directory | [Name]
2-Propenamide, 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(1H-indol-5-ylamino)-2-oxoethyl]-, (2E)- | [CAS]
2761542-55-4 | [Synonyms]
AChE/BChE-IN-9
2-Propenamide, 3-(4-hydroxy-3-methoxyphenyl)-N-[2-(1H-indol-5-ylamino)-2-oxoethyl]-, (2E)- | [Molecular Formula]
C20H19N3O4 | [MOL File]
2761542-55-4.mol | [Molecular Weight]
365.38 |
| Hazard Information | Back Directory | [Uses]
AChE/BChE-IN-9 (Compound 7a) is a potent, orally active AChE and BChE inhibitor with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. AChE/BChE-IN-9 is also an efficacious antioxidant with an IC50 of 57.35 μM. AChE/BChE-IN-9 is able to chelate iron and modulates aggregation of amyloid β1-42. AChE-IN-16 can cross the BBB[1]. | [in vivo]
AChE/BChE-IN-9 (Compound 7a) (0-25 mg/kg) improves spatial memory in cognitive deficit mice[1]. | [References]
[1] Singh YP, et al. Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease. Eur J Med Chem. 2020 Jul 15;198:112257. DOI:10.1016/j.ejmech.2020.112257 |
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