| Identification | Back Directory | [Name]
4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- | [CAS]
2762315-06-8 | [Synonyms]
HIF-1α-IN-2
4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- | [Molecular Formula]
C21H19N3OS | [MOL File]
2762315-06-8.mol | [Molecular Weight]
361.46 |
| Chemical Properties | Back Directory | [Boiling point ]
540.3±50.0 °C(Predicted) | [density ]
1.257±0.06 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [form ]
Solid | [pka]
8.40±0.50(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1]. HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC50s of 28 nM and 15 nM, respectively[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect[1].
HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia[1]. Cell Viability Assay Cell Viability Assay | [Uses]
HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2?suppresses HIF-1α expression by blocking transcription and?protein translation[1]. | [References]
[1] Wu YC, et al. Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors. Bioorg Chem. 2022;121:105681. DOI:10.1016/j.bioorg.2022.105681 |
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