| Identification | Back Directory | [Name]
CD33 splicing modulator 1 | [CAS]
2762547-05-5 | [Synonyms]
CD33 splicing modulator 1
Benzamide, 3-fluoro-4-(6-methylpyrazolo[1,5-a]pyrimidin-3-yl)-N-(3-methyl-2-pyridinyl)-N-(3R)-3-piperidinyl- | [Molecular Formula]
C25H25FN6O | [MOL File]
2762547-05-5.mol | [Molecular Weight]
444.5 |
| Hazard Information | Back Directory | [Uses]
CD33 splicing modulator 1 (Compound 1) is a CD33 splicing modulator. CD33/Siglec 3 is a myeloid lineage cell surface receptor that is known to regulate microglia activity. CD33 splicing modulator 1 increases exon 2 skipping in cellular mRNA pools. CD33 splicing modulator 1 has the potential for the research of neurodegenerative disease including Alzheimer's disease[1]. | [References]
[1] Chappie TA, et al. Discovery of Small-Molecule CD33 Pre-mRNA Splicing Modulators. ACS Med Chem Lett. 2022;13(1):55-62. DOI:10.1021/acsmedchemlett.1c00396 |
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