| Identification | Back Directory | [Name]
1H-Pyrazole-4-carboxamide, 1-[4-(3,4-dichloro-2-oxo-1(2H)-pyridinyl)phenyl]-N-ethyl-5-(trifluoromethyl)- | [CAS]
2763378-71-6 | [Synonyms]
1-(4-(3,4-dichloro-2-oxopyridin-1(2H)-yl)phenyl)-N-ethyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide 1H-Pyrazole-4-carboxamide, 1-[4-(3,4-dichloro-2-oxo-1(2H)-pyridinyl)phenyl]-N-ethyl-5-(trifluoromethyl)- | [Molecular Formula]
C18H13Cl2F3N4O2 | [MOL File]
2763378-71-6.mol | [Molecular Weight]
445.22 |
| Chemical Properties | Back Directory | [Boiling point ]
552.6±50.0 °C(Predicted) | [density ]
1.51±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
11.55±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
JW-65 (compound 20) is a TRPC3 inhibitor. JW-65 can be used in neurological and cardiovascular disease related research[1]. | [IC 50]
TRPC3 | [References]
[1] Zhang S, et al. Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity. ACS Med Chem Lett. 2021 Mar 5;12(4):572-578. DOI:10.1021/acsmedchemlett.0c00571 [2] Nagib MM, et al. Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. Epilepsia. 2022 Apr;63(4):1003-1015. DOI:10.1111/epi.17190 [3] Silva-Cardoso GK, et al. Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats. Eur J Pharmacol. 2024 Aug 15;977:176722. DOI:10.1016/j.ejphar.2024.176722 |
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