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2763378-71-6

2763378-71-6 Structure

2763378-71-6 Structure
IdentificationBack Directory
[Name]

1H-Pyrazole-4-carboxamide, 1-[4-(3,4-dichloro-2-oxo-1(2H)-pyridinyl)phenyl]-N-ethyl-5-(trifluoromethyl)-
[CAS]

2763378-71-6
[Synonyms]

1-(4-(3,4-dichloro-2-oxopyridin-1(2H)-yl)phenyl)-N-ethyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide
1H-Pyrazole-4-carboxamide, 1-[4-(3,4-dichloro-2-oxo-1(2H)-pyridinyl)phenyl]-N-ethyl-5-(trifluoromethyl)-
[Molecular Formula]

C18H13Cl2F3N4O2
[MOL File]

2763378-71-6.mol
[Molecular Weight]

445.22
Chemical PropertiesBack Directory
[Boiling point ]

552.6±50.0 °C(Predicted)
[density ]

1.51±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

11.55±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

JW-65 (compound 20) is a TRPC3 inhibitor. JW-65 can be used in neurological and cardiovascular disease related research[1].
[IC 50]

TRPC3
[References]

[1] Zhang S, et al. Discovery of a Highly Selective and Potent TRPC3 Inhibitor with High Metabolic Stability and Low Toxicity. ACS Med Chem Lett. 2021 Mar 5;12(4):572-578. DOI:10.1021/acsmedchemlett.0c00571
[2] Nagib MM, et al. Inhibition of TRPC3 channels by a novel pyrazole compound confers antiseizure effects. Epilepsia. 2022 Apr;63(4):1003-1015. DOI:10.1111/epi.17190
[3] Silva-Cardoso GK, et al. Inhibition of TRPC3 channels suppresses seizure susceptibility in the genetically-epilepsy prone rats. Eur J Pharmacol. 2024 Aug 15;977:176722. DOI:10.1016/j.ejphar.2024.176722
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