| Identification | Back Directory | [Name]
(S,R,S)-AHPC-PEG6-NH2(dihydrochloride) | [CAS]
2763910-08-1 | [Synonyms]
(S,R,S)-AHPC-PEG6-NH2(dihydrochloride)
(2S,4R)-1-((S)-23-amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride | [Molecular Formula]
C36H58ClN5O10S | [MOL File]
2763910-08-1.mol | [Molecular Weight]
788.4 |
| Hazard Information | Back Directory | [Description]
KZN10081, also known as (S,R,S)-AHPC-PEG6-NH2 hydrochloride, is a ProTAC building block. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker wtih pendant amine for reactivity with a carboxyl group on the target ligand. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate ProTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. This product has no formal name at the moment. | [Uses]
VH 032 amide-PEG6-amine hydrochloride (Step 4) is a functionalized von-Hippel-Lindau protein-ligand (VHL) for PROTAC development, consisting of an E3 ligand and a PEG6 ligand. Terminal amines can be coupled to target protein ligands[1]. | [storage]
Store at -20°C | [References]
[1] Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1.2017-02-23. |
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R&D Systems, Inc
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