| Identification | Back Directory | [Name]
9H-Pyrido[3,4-b]indole-7-carboxamide, 1-[(cyclopropylcarbonyl)amino]-N-[2-[1-[(2-fluorophenyl)methyl]-4-piperidinyl]ethyl]- | [CAS]
2765251-12-3 | [Synonyms]
ZLWH-23
9H-Pyrido[3,4-b]indole-7-carboxamide, 1-[(cyclopropylcarbonyl)amino]-N-[2-[1-[(2-fluorophenyl)methyl]-4-piperidinyl]ethyl]- | [Molecular Formula]
C30H32FN5O2 | [MOL File]
2765251-12-3.mol | [Molecular Weight]
513.61 |
| Hazard Information | Back Directory | [Uses]
ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1]. | [in vivo]
ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model[1]. | [IC 50]
GSK-3β: 6.78 μM (IC50); AChE: 0.27 μM (IC50) | [References]
[1] Liu W, et al. Discovery of novel β-carboline derivatives as selective AChE inhibitors with GSK-3β inhibitory property for the treatment of Alzheimer's disease. Eur J Med Chem. 2022;229:114095. DOI:10.1016/j.ejmech.2021.114095 |
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