| Identification | Back Directory | [Name]
1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde (9CI) | [CAS]
276862-85-2 | [Synonyms]
2-b]pyridine-3-carbaldehyde
4-Azaindole-3-carboxaldehyde
4-Azaindole-3-carboxyaldehyde
4-Azazindole-3-carboxyaldehyde.
4-Azaindole-3-carboxaldehyde 97%
1H-Pyrrolo[3,2-b]pyridine-3-carbaldehyde
1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde
1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde (9CI)
1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde (9CI) ISO 9001：2015 REACH
1H-Pyrrolo[3,2-b]pyridine-3-carboxaldehyde, 3-Formyl-1H-pyrrolo[3,2-b]pyridine | [Molecular Formula]
C8H6N2O | [MDL Number]
MFCD11877845
| [MOL File]
276862-85-2.mol | [Molecular Weight]
146.15 |
| Chemical Properties | Back Directory | [Boiling point ]
361.1±22.0 °C(Predicted) | [density ]
1.368 | [storage temp. ]
Inert atmosphere,2-8°C | [pka]
13.16±0.40(Predicted) | [Appearance]
Light brown to brown Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-azaindole-3-carbaldehyde from 4-azaindole and hexamethylenetetetramine: A mixture of 4-azaindole (0.500 g, 4.223 mmol), hexamethylenetetetramine (0.890 g, 6.348 mmol), and acetic acid (3.630 mL, 63.45 mmol) in water (9 mL) was heated and refluxed for 4 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and concentrated under reduced pressure. The target product 4-azaindole-3-carbaldehyde (0.550 g, 89% yield) was purified by silica gel column chromatography using a gradient elution of dichloromethane with methanol (2% to 4% methanol). The results of mass spectrometry analysis: ESI/APCI(+) m/z: 147 [M+H]+; ESI/APCI(-) m/z: 145 [M-H]-. | [References]
[1] Patent: WO2013/45516, 2013, A1. Location in patent: Page/Page column 198
[2] Patent: US2007/123535, 2007, A1. Location in patent: Page/Page column 35
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5924 - 5934 |
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