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Tubulin inhibitor 41 (Compd D19), a promising anti-GBM (glioblastoma) lead compound and tublin inhibitor with BBB permeability, induces G2/M phase arrest, resulted in cell apoptosis and inhibits the migration of U87 cells[1]. | [in vivo]
Tubulin inhibitor 41 (Compd D19, 5 mg/kg and 10 mg/kg) dose-dependently inhibits the tumor growth of orthotopic glioma xenografts model (GL261-Luc) and effectively prolonged the survival time of mice[1]. | [References]
[1] Haoyi Yang, et al. Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent. Eur J Med Chem. 2024 Feb 8:267:116205. DOI:10.1016/j.ejmech.2024.116205 |
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