Identification | Back Directory | [Name]
Urea, N-[4-[[3-[2-[(trans-4-aminocyclohexyl)amino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]-N'-cyclopropyl- | [CAS]
2771006-45-0 | [Synonyms]
Urea, N-[4-[[3-[2-[(trans-4-aminocyclohexyl)amino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]-N'-cyclopropyl- | [Molecular Formula]
C29H31N7O2 | [MOL File]
2771006-45-0.mol | [Molecular Weight]
509.6 |
Hazard Information | Back Directory | [Uses]
IRE1α kinase-IN-4 (compound 6) is a potent IRE1α inhibitor with an Ki of 140 nM. IRE1α kinase-IN-4 is the ATP-competitive ligands of IRE1α[1]. | [References]
[1] Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17(11):1148-1156. DOI:10.1038/s41589-021-00852-0 |
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