| Hazard Information | Back Directory | [Uses]
IL-1β-IN-1, cannabidiol derivative, is a potent IL-1β inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties[1]. | [in vivo]
IL-1β-IN-1 (compound 2; 10 and 25 mg/kg; i.p.; female Sabra mice) improves swelling and pain sensation in a dose-dependent manner[1]. | Animal Model: | female Sabra mice, 7-8 weeks old[1] | | Dosage: | 10 and 25 mg/kg | | Administration: | intraperitoneal injection | | Result: | Reduced swelling and pain sensation.
Reduced plasma TNFα and IL-1β.
|
| [IC 50]
IL-1β | [References]
[1] Lavi Y, et, al. Novel Synthesis of C-Methylated Phytocannabinoids Bearing Anti-inflammatory Properties. J Med Chem. 2023 Apr 27;66(8):5536-5549. DOI:10.1021/acs.jmedchem.2c01988 |
|
|