| Identification | Back Directory | [Name]
Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- | [CAS]
2782024-58-0 | [Synonyms]
2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
Acetic acid, 2-[4-(2,6-dioxo-3-piperidinyl)phenoxy]- | [Molecular Formula]
C13H13NO5 | [MOL File]
2782024-58-0.mol | [Molecular Weight]
263.25 |
| Hazard Information | Back Directory | [Uses]
Phenyl-glutarimide 4 ’-oxyacetic acid is a carboxylic acid-functionalized cerebellar ligand that can be used in the development of PROTAC deactivators. Phenyl-glutarimide 4 ’-oxyacetic acid binds to PROTAC has better hydrolytic stability and efficacy[1]. | [Biological Activity]
Phenyl-glutarimide 4'-oxyacetic acid is a carboxylic acid-functionalized cereblon ligand that can be used for PROTAC? Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs | [IC 50]
Cereblon | [storage]
Store at -20°C | [References]
[1] Min J, et al. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew Chem Int Ed Engl. 2021 Dec 13;60(51):26663-26670. DOI:10.1002/anie.202108848 |
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