| Identification | Back Directory | [Name]
[(2-oxoindol-3-yl)amino]thiourea | [CAS]
27830-79-1 | [Synonyms]
Isatin-β-thiosemicarbazone
[(2-oxoindol-3-yl)amino]thiourea
(Z)-2-(2-Oxoindolin-3-ylidene)hydrazine-1-carbothioamide
Hydrazinecarbothioamide, 2-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)-, (2Z)- | [Molecular Formula]
C9H8N4OS | [MDL Number]
MFCD00043581 | [MOL File]
27830-79-1.mol | [Molecular Weight]
220.25 |
| Chemical Properties | Back Directory | [Melting point ]
198-200 °C(Solv: ethanol (64-17-5)) | [density ]
1.60±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
9.28±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Isatin-β-thiosemicarbazone is a potent anti-poxvirus agent (including monkeypox virus, orthopoxvirus, vaccinia virus, etc). Isatin-β-thiosemicarbazone also is a potent herpes simplex virus (HSV) inhibitor. Isatin-β-thiosemicarbazone exhibits | [References]
[1] Meis RJ, et al. Genetic and molecular biological characterization of a vaccinia virus gene which renders the virus dependent on isatin-beta-thiosemicarbazone (IBT). Virology. 1991 Jun;182(2):442-54. DOI:10.1016/0042-6822(91)90585-y
[2] Katz E, et al. Synthesis of vaccinia virus polypeptides in the presence of isatin-beta-thiosemicarbazone. Antimicrob Agents Chemother. 1973 Jul;4(1):44-8. DOI:10.1128/AAC.4.1.44
[3] Iou-Jiun Kang, et al. Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1948-52. DOI:10.1016/j.bmcl.2011.02.037
[4] William D Arndt, et al. Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus. Virology. 2016 Oct;497:125-135. DOI:10.1016/j.virol.2016.07.016 |
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