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2785323-62-6

2785323-62-6 Structure

2785323-62-6 Structure
IdentificationBack Directory
[Name]

2-[(4-Chlorophenyl)amino]-N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-4-thiazolecarboxamide
[CAS]

2785323-62-6
[Synonyms]

PROTAC-O4I2
2-[(4-Chlorophenyl)amino]-N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-4-thiazolecarboxamide
[Molecular Formula]

C29H29ClN6O5S
[MOL File]

2785323-62-6.mol
[Molecular Weight]

609.1
Chemical PropertiesBack Directory
[density ]

1.453±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ]

Solid
[pka]

10.75±0.40(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Uses]

PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells[1].
[in vivo]

PROTAC-O4I2 (10 μM) significantly increases survival by interference with the maintenance and proliferation of tumor in a Drosophila intestinal tumor model[1].

Animal Model:Drosophila melanogaster[1]
Dosage:10 μM
Administration:Flies were fed on a round filter paper loaded with PROTAC-O4I2 in a 5% sucrose solution, maintained at 18℃ and flipped into a freshly prepared vial every 2 days
Result:Decreased stem cell activity, blocked the initiation and growth of tumor, and improved the survival of the Drosophila ISC tumor model.
[IC 50]

Cereblon
[References]

[1] Rodrigo A Gama-Brambila, et al. A PROTAC targets splicing factor 3B1. Cell Chem Biol. 2021 Nov 18;28(11):1616-1627.e8. DOI:10.1016/j.chembiol.2021.04.018
Spectrum DetailBack Directory
[Spectrum Detail]

2-[(4-Chlorophenyl)amino]-N-[6-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexyl]-4-thiazolecarboxamide(2785323-62-6)1HNMR
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