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2787598-01-8

2787598-01-8 Structure

2787598-01-8 Structure
IdentificationBack Directory
[Name]

1H-Pyrrole-3-carboxamide, 1-(3-cyano-5-methyl-2-thienyl)-N-(6-methoxy-1H-benzimidazol-2-yl)-2,5-dimethyl-
[CAS]

2787598-01-8
[Synonyms]

1H-Pyrrole-3-carboxamide, 1-(3-cyano-5-methyl-2-thienyl)-N-(6-methoxy-1H-benzimidazol-2-yl)-2,5-dimethyl-
[Molecular Formula]

C21H19N5O2S
[MOL File]

2787598-01-8.mol
[Molecular Weight]

405.47
Chemical PropertiesBack Directory
[density ]

1.38±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.62±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1].
[References]

[1] Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129505. doi:10.1016/j.bmcl.2023.129505 DOI:10.1016/j.bmcl.2023.129505
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