| Identification | Back Directory | [Name]
2-AMINO-2-METHYLSUCCINIC ACID | [CAS]
2792-66-7 | [Synonyms]
A-methyl-dl-aspartic acid
DL-ALPHA-METHYLASPARTIC ACID
ALPHA-METHYL-DL-ASPARTIC ACID
2-AMINO-2-METHYLSUCCINIC ACID | [Molecular Formula]
C5H9NO4 | [MDL Number]
MFCD00056709 | [MOL File]
2792-66-7.mol | [Molecular Weight]
147.13 |
| Chemical Properties | Back Directory | [Melting point ]
234-237 °C (decomp) | [Boiling point ]
259.2±30.0 °C(Predicted) | [density ]
1.414±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.32±0.28(Predicted) | [color ]
White to off-white | [CAS DataBase Reference]
2792-66-7 |
| Hazard Information | Back Directory | [Uses]
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine[1]. | [in vivo]
α-methyl-dl-aspartic acid (147 mg/kg, i.v.) can diminish the l-citrulline-induced retinal vasodilation in Wistar rats[1]. | Animal Model: | Wistar rats | | Dosage: | 147 mg/kg | | Administration: | 147 mg/kg, i.v. | | Result: | Attenuated the increase of retinal arteriolar diameter induced by L-citrulline. |
| [References]
[1] Asami Mori, et al. l-Citrulline dilates rat retinal arterioles via nitric oxide- and prostaglandin-dependent pathways in vivo. J Pharmacol Sci. 2015 Apr;127(4):419-23. DOI:10.1016/j.jphs.2015.02.012
[2] Juliano R Guerreiro, et al. Argininosuccinate synthetase is a functional target for a snake venom anti-hypertensive peptide: role in arginine and nitric oxide production. J Biol Chem. 2009 Jul 24;284(30):20022-33. DOI:10.1074/jbc.M109.021089 |
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